How to investigate evidence and biological convergence in NeuropathIQ
See evidence-connected genes, pathways, and processes.
Open each relationship's supporting publications and identifiers.
See where disease-connected genes converge on a shared pathway.
Read Research Insight's bounded interpretation of the pattern.
NeuropathIQ organizes neurological research into an evidence-grounded network of diseases, genes, pathways, and processes, each traceable to its supporting publications. It is an investigation tool — it surfaces patterns to examine, not biological truth, causality, or clinical significance.
Search opens the connected evidence for a disease, gene, pathway, or biological process — it is not a keyword search over publications. If an entity does not appear in the graph, it may simply fall outside NeuropathIQ's current evidence coverage.
Examples: Parkinson's Disease, the genes PINK1 and ATG5, and PINK1-PRKN Mediated Mitophagy — the running example used throughout this guide.
The Knowledge Graph displays the structure connected to your selection, with each node labeled Disease, Gene, Reactome Pathway, or Biological Process. It is a visualization, not a complete inventory — the side panel and Entity Details show more than the canvas alone.
Disease–gene relationships can converge on a shared pathway. Parkinson's Disease connects to both PINK1 (four separate publications) and ATG5 (one), none shared between them, and Reactome separately maps both to PINK1-PRKN Mediated Mitophagy:
Reactome separately identifies PINK1 and ATG5 as participants in the PINK1-PRKN Mediated Mitophagy pathway. Although the supporting publications associate these genes with Parkinson's Disease, they do not directly establish the pathway's involvement in the disease. NeuropathIQ brings these separate findings together to highlight a biological connection worth investigating, rather than a confirmed disease mechanism.
NeuropathIQ treats these as two distinct kinds of evidence:
Derived from qualifying publications; supports the disease–gene observation only.
Reactome and Gene Ontology place genes within pathways — not evidence the disease is involved.
Open the supporting publication yourself — NeuropathIQ does not replace reading the paper. Each includes whichever identifier is available (a PubMed PMID or OpenAlex Work ID) with a link to the record.
Research Insight is NeuropathIQ's AI-assisted interpretation layer over deterministic, evidence-grounded graph results.
Research Insight is derived analysis, not source evidence. Generating it opens NeuropathIQ's full reading workspace directly, covering why the pattern surfaced, its connecting genes, research questions worth pursuing, and its stated limitations. Sources & Provenance — the specific supporting publications, each correctly labeled PMID or OpenAlex, and the ontology relationships behind it — are shown expanded by default.
When available, it also uses open-access full text alongside abstracts, and states when it did. Research Insight does not create graph relationships, decide what enters the graph, or establish causality, mechanism, or clinical significance.
Disease pages group pathways that are shared across NeuropathIQ's six researcher-facing diseases, even when their underlying publications are not shared. This is convergence for investigation. It is not evidence of a shared disease mechanism.
ClinicalTrials.gov studies appear as research activity, not literature evidence. A trial listed for a disease is not evidence that a gene or pathway relationship exists.
Ready to start? Begin with a disease or gene on the Knowledge Graph.
Explore the Knowledge Graph →